Structural formula
| Business number | 018W |
|---|---|
| Molecular formula | C13H19NO4S |
| Molecular weight | 285.36 |
| label |
p-(dipropylsulfamic acid) benzoic acid, p-(Dipropylsulfamoyl)benzoic acid |
Numbering system
CAS number:57-66-9
MDL number:MFCD00038402
EINECS number:200-344-3
RTECS number:DG9400000
BRN number:None
PubChem number:24898976
Physical property data
1. Appearance: white crystalline powder .
2. Density ( g/mL,25/4℃) : Undetermined
3. Relative vapor density (g/mL,AIR=1): Undetermined
4. Melting point ( oC): 194-196
5. Boiling point ( oC,Normal pressure): Undetermined
6. Boiling point ( oC,5.2kPa): Undetermined
7. Refractive Index: Undetermined
8. Flashpoint (oC): Undetermined
9. Specific optical rotation (o): Undetermined
10. Autoignition point or ignition temperature (oC): Not OK
11. Vapor pressure (kPa,25oC): Undetermined
12. Saturation vapor pressure (kPa,60oC): Undetermined
13. heat of combustion (KJ/mol): Not OK
14. Critical temperature (oC): Undetermined
15. Critical Pressure (KPa): Undetermined
16. Oil and water (octanol/Water) partition coefficient pair Value: Undetermined
17. Explosion limit (%,V/V): Not OK
18. Lower explosion limit (%,V/V): Undetermined
19. Solubility: soluble in acetone , slightly soluble in ethanol or chloroform, almost insoluble in water. Soluble in dilute sodium hydroxide solution, almost insoluble in dilute acid. Odorless, slightly bitter taste.
Toxicological data
None
Ecological data
None
Molecular structure data
5. Molecular property data:
1. Molar refractive index: 73.50
2. Molar volume (m3/mol）：233.5
3. isotonic specific volume (90.2K):610.4
4. Surface Tension (dyne/cm):46.7
5. Polarizability(10-24cm3):29.14
Compute chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 1
3. Number of hydrogen bond acceptors: 5
4. Number of rotatable chemical bonds: 7
5. Number of tautomers: none
6. Topological molecule polar surface area 83.1
7. Number of heavy atoms: 19
8. Surface charge: 0
9. Complexity: 374
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 0
12. Uncertain number of atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Properties and stability
None
Storage method
This product should be sealed in4 Store dry at ℃.
Synthesis method
p-Toluenesulfonamide is oxidized to p-carboxybenzenesulfonamide by sodium dichromate, and then used bromopropane Alkylation reaction, the resulting probenecid sodium is acidified with acetic acid to obtain probenecid.
Purpose
Anti-gout drugs. This product is an organic acid with strong fat solubility. It is excreted from the renal tubules and is easily absorbed back into the body. Therefore, in the presence of propanesulfonate, the operation of certain organic acids in the body’s renal tubules will be inhibited, reducing the excretion of other organic acids. Therefore, it is safe and effective for the treatment of chronic gout. It has no effect on the pain and inflammation of acute gout and is not suitable for acute gout.
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